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Home >> Antibodies >> MMP2 Antibody

MMP2 Antibody [clone BBA-13] (RQ5213)

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Image RQ5213 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 429
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IHC staining of FFPE human breast cancer with MMP2 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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IHC staining of FFPE human breast cancer with MMP2 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
Western blot testing of 1) rat L6 and 2) human HeLa cell lysate with MMP2 antibody. Expected molecular weight: ~72 kDa (pro form), ~63 kDa (cleaved form).
Availability 1-2 weeks
Species Reactivity Human, Rat
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name BBA-13
Purity Affinity purified
UniProt P08253
Applications Western blot : 1:500-1:2000
Immunohistochemistry (FFPE) : 1:50-1:200
Limitations This MMP2 antibody is available for research use only.
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Description

The MMP2 gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. [RefSeq]

Application Notes

Optimal dilution of the MMP2 antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human MMP2 was used as the immunogen for the MMP2 antibody.

Storage

Store the MMP2 antibody at -20oC.

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