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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
The stated application concentrations are suggested starting points. Titration of the MMP14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 145-174 from the human protein was used as the immunogen for the MMP14 antibody.
Aliquot the MMP14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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