- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Collagenase 1 Antibody detects MMP1, a zinc-dependent extracellular protease responsible for initiating the degradation of fibrillar collagens within connective tissues. Commonly referred to as Collagenase 1, MMP1 cleaves collagen types I, II and III, making it an important enzyme in extracellular matrix remodeling, wound repair and normal tissue turnover. Tight regulation of Collagenase 1 activity is essential for maintaining tissue integrity while permitting controlled remodeling during development, healing and inflammatory responses.
Collagenase 1 is produced by a variety of cell types, including fibroblasts, epithelial cells, endothelial cells and inflammatory cells following stimulation by cytokines, growth factors and tissue injury. After secretion, the enzyme participates in remodeling the extracellular matrix by degrading structural collagen fibers, facilitating cell migration and regulating interactions between cells and their surrounding microenvironment. A Collagenase 1 Antibody is useful for investigating connective tissue biology, extracellular matrix regulation and mechanisms of tissue repair.
Abnormal expression of Collagenase 1 has been associated with numerous pathological conditions, including cancer, arthritis, pulmonary fibrosis and chronic inflammatory diseases. Increased MMP1 activity may promote tumor invasion and metastasis by disrupting extracellular matrix barriers surrounding malignant cells. Because of these important biological functions, Collagenase 1 / CLG remains a widely studied biomarker in oncology, inflammation and tissue remodeling research.
Collagenase 1 functions within a complex network of matrix metalloproteinases and their endogenous inhibitors, where coordinated regulation determines the balance between extracellular matrix degradation and preservation. Analysis of Collagenase 1 expression provides valuable insight into proteolytic signaling, stromal remodeling and disease-associated changes in connective tissue architecture. Collagenase 1 Antibody supports studies examining extracellular protease activity, matrix turnover and cellular interactions within remodeling tissues.
NSJ Bioreagents offers Collagenase 1 Antibody products for researchers studying extracellular matrix biology, connective tissue remodeling and cancer progression. These antibodies support applications including Western blot, immunohistochemistry, immunofluorescence and flow cytometry analysis of MMP1 expression and localization. Collagenase 1 Antibody provides a valuable tool for investigating collagen degradation, tumor invasion and extracellular matrix remodeling pathways.
Researchers studying matrix metalloproteinase biology and extracellular matrix remodeling may also be interested in our MMP1 Antibody / Interstitial Collagenase Antibody page, which highlights MMP1 function in tumor invasion, collagen degradation and cancer-associated extracellular matrix remodeling.
Optimal dilution of the Collagenase 1 Antibody should be determined by the researcher.
A synthetic peptide specific to human MMP1 was used as the immunogen for the MMP1 / Collagenase 1 antibody.
Store the MMP1 / Collagenase 1 antibody at -20oC.
MMP1 antibody, Interstitial Collagenase antibody, Fibroblast Collagenase antibody, Matrix Metalloproteinase 1 antibody, MMP-1 antibody, CLG antibody
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