- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MITA Antibody STING1/8129R / Mediator of IRF3 activation Antibody [clone STING1/8129R] (V5100)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5100-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5100-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V5100SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | STING1/8129R |
| Purity | Protein A/G affinity |
| UniProt | Q86WV6 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This MITA antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Stimulator of interferon genes protein (STING1), also known as MITA (Mediator of IRF3 activation), ERIS (endoplasmic reticulum interferon stimulator), or TMEM173, is an intracellular adaptor protein that functions as a central regulator of cytosolic DNA sensing and innate immune signaling. MITA Antibody STING1/8129R recognizes STING1, a signaling protein localized primarily to the endoplasmic reticulum where it participates in activation of antiviral interferon responses. STING1 is a critical component of the cyclic GMP-AMP synthase (cGAS)-STING pathway, which detects abnormal cytoplasmic DNA originating from viral infection, intracellular bacteria, mitochondrial damage, or genomic instability.
When cytosolic DNA is detected, cGAS catalyzes formation of the cyclic dinucleotide cGAMP, which binds directly to STING1 and triggers conformational activation of the protein. Activated STING translocates from the endoplasmic reticulum to Golgi-associated vesicles where it recruits signaling molecules including TBK1 and the transcription factor IRF3. This interaction leads to phosphorylation and activation of IRF3, resulting in transcription of type I interferons and inflammatory cytokines. Because of this function, STING1 is frequently referred to as Mediator of IRF3 activation, reflecting its essential role in linking DNA sensing to interferon production.
STING1 is broadly expressed across immune and non-immune cell types including macrophages, dendritic cells, epithelial cells, and endothelial cells. Activation of the cGAS-STING pathway is a key component of host defense against viral infection and intracellular pathogens. In addition to antimicrobial immunity, STING signaling has been implicated in cancer immunology, autoinflammatory disorders, and responses to DNA damage. Dysregulation of STING activity can contribute to excessive inflammatory responses or immune-mediated disease.
A recombinant rabbit monoclonal antibody such as clone STING1/8129R supports detection of STING1 protein in research applications examining innate immune signaling pathways. Antibodies targeting MITA/STING1 are widely used to study interferon pathway activation, cytosolic DNA sensing, and the regulation of innate immune responses involved in host defense and inflammatory disease mechanisms.
Optimal dilution of the MITA Antibody STING1/8129R should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the MITA antibody.
Aliquot the MITA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
STING antibody, STING1 antibody, TMEM173 antibody, ERIS antibody, Stimulator of interferon genes protein antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
