- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MFN1 Antibody / Mitofusin-1 (R31677)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R31677 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| Gene ID | 55669 |
| Applications | Western blot : 0.5-1ug/ml |
| Limitations | This MFN1 antibody is available for research use only. |
|
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Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is a mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN�2, and to undergo ubiquitination by MARCH5. It has two key domains; One is a coiled�coil region that mediates MFN�1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion. Overexpression causes perinuclear mitochondrial clustering.
The stated application concentrations are suggested starting amounts. Titration of the MFN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the N-terminal of human Mitofusin 1 (DQLLEFVTEGSHFVEATYKNPELDRIA) was used as the immunogen for this MFN1 antibody.
After reconstitution, the MFN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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