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Home >> Antibodies >> Mesothelin Antibody Mouse Monoclonal / MSLN

Mesothelin Antibody Mouse Monoclonal / MSLN [clone MSLN/3383] (V5642)

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  Catalog No Formulation Size Price (USD)  
Image V5642-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V5642-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V5642SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
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Western blot analysis of Mesothelin antibody in human OVCAR-3 cell lysate. A prominent band is observed at approximately 40-45 kDa, consistent with the cleaved membrane-associated form of Mesothelin, while the full-length precursor is predicted at approximately 69 kDa. Mesothelin is a glycoprotein and glycosylation can contribute to apparent molecular weight shifts on SDS-PAGE. Mouse monoclonal (Clone MSLN/3383) was used for detection.
SDS-PAGE analysis of purified, BSA-free mouse monoclonal Mesothelin antibody (clone MSLN/3383) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name MSLN/3383
Purity Protein G affinity
UniProt Q13421
Localization Cell membrane, Golgi apparatus, Secreted
Applications Western Blot : 1-2ug/ml
Limitations This Mesothelin antibody is available for research use only.
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Description

Mesothelin Antibody Mouse Monoclonal recognizes Mesothelin, a glycosylphosphatidylinositol-anchored cell surface protein encoded by the MSLN gene. Mesothelin is physiologically expressed on mesothelial cells lining the pleura, peritoneum, and pericardium, where it localizes predominantly to the cell membrane. Mesothelin Antibody Mouse Monoclonal clone MSLN/3383 is designed for research applications investigating mesothelial biology and mesothelin expression in human tumors.

Mesothelin is synthesized as a precursor protein that undergoes proteolytic processing to generate a membrane-bound mature mesothelin fragment and a soluble fragment known as megakaryocyte potentiating factor. In normal tissues, expression is limited mainly to mesothelial surfaces. In contrast, mesothelin is frequently overexpressed in several epithelial malignancies, including malignant mesothelioma, ovarian carcinoma, pancreatic ductal adenocarcinoma, and subsets of lung and gastric carcinomas. In these tumors, staining is commonly observed along the cell membrane of malignant epithelial cells, sometimes accompanied by cytoplasmic reactivity depending on tissue handling and expression level.

Because mesothelin shows restricted distribution in normal tissues and elevated expression in multiple cancers, it has been extensively studied in tumor biology, biomarker research, and experimental therapeutic targeting strategies. Its expression pattern makes it a useful marker in research evaluating tumor phenotype and cell surface protein expression in mesothelin-positive malignancies.

Mesothelin Antibody Mouse Monoclonal clone MSLN/3383 provides a tool for detecting MSLN expression in human tissue samples and experimental models. This monoclonal antibody is suitable for research applications focused on mesothelial tissues and mesothelin-expressing tumors.

Application Notes

Optimal dilution of the Mesothelin antibody should be determined by the researcher.

Immunogen

A portion of amino acids 273-407 from human Mesothelin protein was used as the immunogen for the Mesothelin antibody.

Storage

Aliquot the Mesothelin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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