- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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MERTK Polyclonal Antibody / Mer Tyrosine Kinase Antibody recognizes MER proto-oncogene tyrosine kinase, a member of the TAM receptor tyrosine kinase family together with AXL and TYRO3. MERTK is also known as MerTK, MER, c-Mer and Eyk. The receptor participates in cellular signaling pathways that regulate phagocytosis, survival, migration and immune homeostasis and is particularly important for the recognition and clearance of apoptotic cells.
MERTK is a single-pass transmembrane protein containing two extracellular immunoglobulin-like domains, two fibronectin type III domains and an intracellular tyrosine kinase domain. Its extracellular region interacts with the ligands GAS6 and Protein S, which can bridge the receptor to phosphatidylserine exposed on apoptotic cells. Receptor activation promotes intracellular signaling that facilitates engulfment of apoptotic material through efferocytosis while helping regulate inflammatory responses associated with dying cells.
MERTK function is particularly important in macrophages and other professional phagocytes. Clearance of apoptotic cells helps maintain tissue homeostasis and prevents the accumulation of cellular debris that could otherwise promote inflammation. Mer Tyrosine Kinase Antibody reagents are therefore useful for investigating the relationship between TAM receptor signaling, phagocyte biology and regulation of innate immune responses.
MERTK also has an important role in retinal pigment epithelial cells, where it participates in phagocytic removal of shed photoreceptor outer segments. Loss-of-function mutations in the MERTK gene can disrupt this process and are associated with inherited retinal degeneration, including forms of retinitis pigmentosa. Aberrant MERTK expression and signaling are additionally investigated in cancer, where receptor activity can influence tumor cell survival and the immune characteristics of the tumor microenvironment.
NSJ Bioreagents offers this affinity-purified rabbit polyclonal reagent for research into MERTK expression and receptor biology. The MERTK Polyclonal Antibody terminology emphasizes the official gene symbol and polyclonal format, while Mer Tyrosine Kinase Antibody provides an expanded target-name search term.
A MERTK Polyclonal Antibody provides a reagent for investigating MERTK expression and TAM-family biology, while a Mer Tyrosine Kinase Antibody supports research into efferocytosis, immune regulation and receptor tyrosine kinase signaling.
For a Protein Microarray Validated monoclonal antibody to this target, see our MerTK Antibody MERTK/3015 / MERTK Monoclonal Antibody.
Optimal dilution of the MERTK Polyclonal Antibody / Mer Tyrosine Kinase Antibody should be determined by the researcher.
An E. coli-derived human protein (amino acids A21-A489) was used as the immunogen for the MERTK Polyclonal Antibody.
After reconstitution, the MERTK Polyclonal Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Mer Tyrosine Kinase antibody, MerTK antibody, MER antibody, c-Mer antibody, Mer Receptor Tyrosine Kinase antibody, MER Proto-Oncogene Tyrosine Kinase antibody, Eyk antibody
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