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Home >> Antibodies >> MERTK Antibody MERTK/3024 / c-Mer Antibody

MERTK Antibody MERTK/3024 / c-Mer Antibody [clone MERTK/3024] (V8863)

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  Catalog No Formulation Size Price (USD)  
Image V8863-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V8863-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V8863SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Microvalidated
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MERTK Antibody MERTK/3024 Immunohistochemistry. IHC staining of FFPE human colon carcinoma tissue with MERTK antibody (clone MERTK/3024). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human colon carcinoma tissue with MERTK antibody (clone MERTK/3024). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using MERTK antibody (clone MERTK/3024). These results demonstrate the foremost specificity of the MERTK/3024 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
SDS-PAGE analysis of purified, BSA-free MERTK antibody (clone MERTK/3024) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2a
Clone Name MERTK/3024
Purity Protein A/G affinity
UniProt Q12866
Localization Cell surface
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This MERTK Antibody MERTK/3024 / c-Mer Antibody is available for research use only.
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Description

MERTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MERTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MERTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MERTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MERTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
For a Protein Microarray Validated monoclonal antibody to this target, see our MerTK Antibody MERTK/3015 / MERTK Monoclonal Antibody.

Application Notes

Optimal dilution of the MERTK Antibody MERTK/3024 / c-Mer Antibody should be determined by the researcher.

Immunogen

A portion of amino acids 55-148 was used as the immunogen for the MERTK Antibody MERTK/3024.

Storage

Aliquot the MERTK Antibody MERTK/3024 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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