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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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MerTK Antibody MERTK/3015 / MERTK Monoclonal Antibody recognizes MER proto-oncogene tyrosine kinase, a member of the TAM receptor tyrosine kinase family together with AXL and TYRO3. MerTK is also known as MERTK, MER, c-Mer and Eyk. The receptor participates in cellular signaling pathways that regulate phagocytosis, survival, migration and immune homeostasis and is particularly important for the recognition and clearance of apoptotic cells.
MerTK is a single-pass transmembrane protein containing two extracellular immunoglobulin-like domains, two fibronectin type III domains and an intracellular tyrosine kinase domain. Its extracellular region interacts indirectly with phosphatidylserine exposed on apoptotic cells through bridging ligands such as GAS6 and Protein S. Receptor activation promotes intracellular signaling that facilitates engulfment of apoptotic material, a process known as efferocytosis, while helping limit inflammatory responses to dying cells.
MERTK function is important in macrophages and other professional phagocytes and also contributes to retinal pigment epithelial cell biology. In the retina, MerTK participates in the phagocytic removal of shed photoreceptor outer segments. Loss-of-function mutations in MERTK can disrupt this process and are associated with inherited retinal degeneration, including forms of retinitis pigmentosa.
Aberrant MERTK expression and signaling are also investigated in cancer biology. Increased receptor activity can promote cell survival and other signaling programs favorable to tumor progression, while MerTK-dependent clearance of apoptotic cells may contribute to an immunosuppressive tumor microenvironment. These functions have made the receptor an important subject in studies of TAM-family signaling, innate immunity, efferocytosis and cancer biology.
NSJ Bioreagents offers clone MERTK/3015 for research into MerTK expression and receptor biology. The MerTK Antibody terminology reflects the commonly used protein designation, while MERTK Monoclonal Antibody emphasizes the official gene symbol and monoclonal format of the reagent.
A MerTK Antibody provides a reagent for investigating MER receptor expression and TAM-family biology, while MERTK Monoclonal Antibody supports research into efferocytosis, immune regulation and receptor tyrosine kinase signaling.
This MerTK Antibody is part of our Innate Immunity Antibodies collection.
Optimal dilution of the MerTK Antibody MERTK/3015 / MERTK Monoclonal Antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 55-148) was used as the immunogen for the MerTK Antibody MERTK/3015.
Store the MerTK Antibody MERTK/3015 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
MERTK antibody, MER antibody, c-Mer antibody, Mer Receptor Tyrosine Kinase antibody, MER Proto-Oncogene Tyrosine Kinase antibody, Eyk antibody
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