- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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MERTK Rabbit Polyclonal Antibody / MER Receptor Tyrosine Kinase Antibody recognizes MER proto-oncogene tyrosine kinase, a member of the TAM receptor tyrosine kinase family together with AXL and TYRO3. MERTK is also known as MerTK, MER, c-Mer and Eyk. The receptor participates in signaling pathways that regulate phagocytosis, cell survival, migration and immune homeostasis and has an important role in the recognition and clearance of apoptotic cells.
MERTK is a single-pass transmembrane protein containing two extracellular immunoglobulin-like domains, two fibronectin type III domains and an intracellular tyrosine kinase domain. The TAM ligands GAS6 and Protein S can bridge MERTK to phosphatidylserine exposed on apoptotic cells. Receptor activation initiates intracellular signaling that promotes engulfment of apoptotic material through efferocytosis while helping regulate inflammatory responses and maintain tissue homeostasis.
MERTK function is particularly important in macrophages and other professional phagocytes, where efficient removal of dying cells prevents the accumulation of cellular debris and limits inappropriate inflammatory responses. The receptor also has an essential role in retinal pigment epithelial cells, which use MERTK-dependent phagocytosis to remove shed photoreceptor outer segments. Loss-of-function mutations in MERTK are associated with inherited retinal degeneration, including forms of autosomal recessive retinitis pigmentosa.
Aberrant MERTK expression and signaling are additionally investigated in cancer biology. Increased receptor activity can promote cellular survival and other signaling programs associated with tumor progression, while MERTK-dependent efferocytosis can influence immune regulation within the tumor microenvironment. A MER Receptor Tyrosine Kinase Antibody therefore provides a useful reagent for investigating TAM-family biology across immune, retinal and cancer research.
NSJ Bioreagents offers this rabbit polyclonal reagent for research into MERTK expression and receptor biology. The MERTK Rabbit Polyclonal Antibody terminology distinguishes the host species and polyclonal format, while MER Receptor Tyrosine Kinase Antibody provides an expanded target-name search term.
A MERTK Rabbit Polyclonal Antibody provides a reagent for investigating MERTK expression and TAM-family biology, while a MER Receptor Tyrosine Kinase Antibody supports research into efferocytosis, immune regulation and receptor tyrosine kinase signaling.
Titration of the MERTK Rabbit Polyclonal Antibody / MER Receptor Tyrosine Kinase Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This MERTK Rabbit Polyclonal Antibody was produced from rabbits immunized with a his tag recombinant protein of human MERTK.
Aliquot the MERTK Rabbit Polyclonal Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
MER Receptor Tyrosine Kinase antibody, MerTK antibody, MER antibody, c-Mer antibody, Mer Tyrosine Kinase antibody, MER Proto-Oncogene Tyrosine Kinase antibody, Eyk antibody
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