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Home >> Antibodies >> Melk Antibody

Melk Antibody (F53274)

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  Catalog No Formulation Size Price (USD)  
Image F53274-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F53274-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot testing of Melk antibody at 1:1000 dilution. Lane 1: mouse spleen lysate; 2: mouse thymus lysate; Predicted molecular weight ~ 73 kDa.
Western blot testing of Melk antibody at 1:1000 dilution. Lane 1: mouse spleen lysate; 2: mouse thymus lysate; Predicted molecular weight ~ 73 kDa.
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q61846
Applications Western blot : 1:1000
Limitations This Melk antibody is available for research use only.
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Description

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

Application Notes

Titration of the Melk antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This mouse Melk antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 381-415 amino acids from the Central region of mouse Melk.

Storage

Aliquot the Melk antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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