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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Med22 is a subunit of the RNA polymerase II (Pol II) transcriptional mediator complex. The mediator complex is a coactivator involved in the regulated transcription of Pol II-dependent genes. Functioning as a bridge to convey information from gene-specific regulatory proteins to the basal Pol II transcription machinery, the mediator complex is recruited to promoter regions by directly interacting with regulatory proteins. The mediator complex also serves as a scaffold for the assembly of a functional pre-initiation complex with Pol II and other general transcription factors. Med22 (mediator complex subunit 22), also known as SURF5 (surfeit locus protein 5), is a ubiquitously expressed 200 amino acid nuclear protein that is one of several components of the mediator complex. There are two isoforms of Med22 that are produced as a result of alternative splicing events.
Optimal dilution of the MED22 antibody should be determined by the researcher.
Recombinant full-length human protein was used as the immunogen for the MED22 antibody.
Aliquot the MED22 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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