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Home >> Antibodies >> MDM2 Antibody

MDM2 Antibody [clone SMP14] (V7950)

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  Catalog No Formulation Size Price (USD)  
Image V7950-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7950-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7950SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Western blot testing of human HepG2 cell lysate with MDM2 antibody (clone SMP14). Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.
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Western blot testing of human HepG2 cell lysate with MDM2 antibody (clone SMP14). Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.
IHC staining of FFPE human breast cancer with MDM2 antibody (clone SMP14). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free MDM2 antibody (clone SMP14) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name SMP14
Purity Protein G affinity chromatography
UniProt Q00987
Localization Nuclear
Applications ELISA (order BSA-free format for coating) :
Western blot : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This MDM2 antibody is available for research use only.
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Description

MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.

Application Notes

Optimal dilution of the MDM2 antibody should be determined by the researcher.

Immunogen

Amino acids 154-167 were used as the immunogen for the MDM2 antibody.

Storage

Store the MDM2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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