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Home >> Antibodies >> MDM2 Antibody

MDM2 Antibody (R30449)

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  Catalog No Formulation Size Price (USD)  
Image R30449 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of MDM2 antibody and Lane 1: rat testis; 2: rat brain; 3: rat heart; 4: human SKOV-3; 5: COLO320; 6: HeLa; 7: mouse HEPA; 8: monkey COS7 cell lysate. Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.
Western blot testing of MDM2 antibody and Lane 1: rat testis; 2: rat brain; 3: rat heart; 4: human SKOV-3; 5: COLO320; 6: HeLa; 7: mouse HEPA; 8: monkey COS7 cell lysate. Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q00987
Applications Western blot : 0.5-1ug/ml
Limitations This MDM2 antibody is available for research use only.
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Description

MDM2 is an important negative regulator of the p53 tumor suppressor. The protein functions both as an E3 ubiquity lipase that recognizes the N-terminal trans-activation domain(TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Oliner et al.(1992) used MDM2 clones to localize the human gene to chromosome 12q13-q14 by analysis of human-hamster somatic cell hybrids.

Application Notes

The stated application concentrations are suggested starting points. Titration of the MDM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Amino acids 343-358 (EKAKLENSTQAEEGFD) were used as the immunogen for this MDM2 antibody.

Storage

After reconstitution, the MDM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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