- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MDM2 Antibody [clone MDM2/3277] (V8985)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8985-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
|
V8985-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
|
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V8985SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | MDM2/3277 |
| Purity | Protein A/G affinity |
| UniProt | Q00987 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This MDM2 antibody is available for research use only. |
|
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MDM2 antibody detects mouse double minute 2 homolog, an E3 ubiquitin-protein ligase encoded by the MDM2 gene. MDM2 is a critical regulator of p53, functioning as its primary negative regulator by ubiquitinating and targeting it for degradation. Because MDM2 controls p53 stability and thereby influences cell cycle arrest, apoptosis, and DNA repair, MDM2 antibody is essential in oncology, molecular biology, and therapeutic research.
MDM2 contains a p53-binding domain, a nuclear localization signal, and a RING finger E3 ligase domain. Under normal conditions, it maintains low p53 levels, preventing unnecessary growth arrest. In stress or DNA damage, post-translational modifications disrupt this interaction, stabilizing p53 and allowing tumor suppressor responses. Overexpression of MDM2, observed in many cancers, attenuates p53 activity and supports tumor progression.
The MDM2 antibody clone MDM2/3277 provides specific and reproducible recognition. Clone MDM2/3277 has been cited in peer-reviewed research exploring p53 regulation, cancer pathogenesis, and therapeutic inhibition of the MDM2-p53 interaction. Its reproducibility makes it suitable for immunohistochemistry, immunoblotting, and mechanistic studies of protein regulation.
Research using clone MDM2/3277 has demonstrated that MDM2 amplification contributes to oncogenesis by suppressing p53-mediated apoptosis. In translational studies, MDM2 detection has guided therapeutic development of small-molecule inhibitors that block its interaction with p53, restoring tumor suppressor function. This antibody has also been used to study MDM2âs roles beyond p53 regulation, including its interactions with other transcription factors and E2F signaling pathways.
NSJ Bioreagents provides this MDM2 antibody to support oncology, molecular biology, and therapeutic development. Alternate designations include HDM2 antibody, murine double minute 2 homolog antibody, p53-binding protein antibody, E3 ubiquitin-protein ligase MDM2 antibody, and oncogenic regulator antibody.
Optimal dilution of the MDM2 antibody should be determined by the researcher.
A portion of amino acids 126-254 was used as the immunogen for the MDM2 antibody.
Aliquot the MDM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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