MCM7 Antibody for IHC / Minichromosome Maintenance Protein 7 Antibody [clone MSVA-507R] (V6095)

MCM7 Antibody for IHC - immunohistochemistry staining across human normal and cancer tissues. Tissue microarrays of FFPE human normal and tumor tissues were stained with MCM7 Antibody for IHC (clone MSVA-507R), a recombinant rabbit monoclonal antibody targeting Minichromosome maintenance protein 7 / MCM7. Nuclear HRP-DAB brown chromogenic staining highlights proliferating cell populations in several tissues, including strong staining of germinal center lymphocytes in lymph node and tonsil, intestinal epithelial cells within colon and appendix mucosa, proliferative compartments of the endometrium, and subsets of epithelial cells in tissues such as testis and bronchial mucosa. Many differentiated tissues including skeletal muscle, heart muscle, and mature stromal compartments show little or no staining, consistent with the lower proliferative activity of these cells. Across the cancer tissue panel, strong nuclear staining is observed in multiple tumor types including colorectal carcinoma, breast carcinoma, lung carcinoma, and lymphoid malignancies, reflecting the elevated DNA replication activity of proliferating tumor cells. The observed staining patterns across the normal and cancer tissue panels align with published expression profiles reported in the Human Protein Atlas.