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Home >> Antibodies >> MCM2 Antibody

MCM2 Antibody [clone MCM2/8006R] (V4990)

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  Catalog No Formulation Size Price (USD)  
Image V4990-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4990-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4990SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human ovarian carcinoma tissue with MCM2 antibody (clone MCM2/8006R). Inset: PBS instead of primary antibody, secondary only control.
IHC staining of FFPE human ovarian carcinoma tissue with MCM2 antibody (clone MCM2/8006R). Inset: PBS instead of primary antibody, secondary only control.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name MCM2/8006R
Purity Protein A/G affinity
UniProt P49736
Localization Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This MCM2 antibody is available for research use only.
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Description

The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.

Application Notes

Optimal dilution of the MCM2 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the MCM2 antibody.

Storage

Aliquot the MCM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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