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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
For an alternative antibody targeting the same cell adhesion molecule, see our MCAM Antibody MCAM/3046, a mouse monoclonal antibody featuring human melanoma IHC and protein microarray specificity validation.
Optimal dilution of the MCAM Antibody MCAM/3048 should be determined by the researcher.
A recombinant human partial protein (amino acids 226-374) was used as the immunogen for the MCAM Antibody MCAM/3048.
Store the MCAM Antibody MCAM/3048 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
MCAM antibody, MUC18 antibody, Mel-CAM antibody, Melanoma Cell Adhesion Molecule antibody, Cell Surface Glycoprotein MUC18 antibody, CD146 Antigen antibody, Recombinant MCAM antibody, Recombinant MUC18 antibody
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