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Home >> Antibodies >> Anti-MBP Antibody

Anti-MBP Antibody [clone 408CT17.4.3] (F53611)

  Catalog No Formulation Size Price (USD)  
Image F53611-0.1ML In ascites with 0.09% sodium azide 0.1 ml 329
Anti-MBP antibody western blot analysis in ZR-75-1 lysate. Multiple isoforms visualized from 20~37 kDa.
Confocal immunofluorescent analysis of anti-MBP antibody with NCI-H460 cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used as a nuclear counterstain (blue).
Availability 1-3 business days
Species Reactivity Human
Format Ascites
Clonality Monoclonal (mouse origin)
Isotype Mouse IgM
Clone Name 408CT17.4.3
Purity Ascites
UniProt P02686
Applications Western blot : 1:5000-1:16000
Immunofluorescence : 1:10-1:50
Limitations This anti-MBP antibody is available for research use only.
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Description

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq].

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the anti-MBP antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Purified His-tagged protein fragment was used to produced this monoclonal anti-MBP antibody.

Storage

Aliquot the anti-MBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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