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Home >> Antibodies >> Matrix metalloproteinase 9 Antibody / MMP9

Matrix metalloproteinase 9 Antibody / MMP9 [clone 2C3] (V7961)

  Catalog No Formulation Size Price (USD)  
Image V7961-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7961-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7961SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human spleen with Matrix metalloproteinase 9 antibody (clone 2C3). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Matrix metalloproteinase 9 antibody (clone 2C3) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name 2C3
Purity Protein G affinity chromatography
UniProt P14780
Localization Cytoplasmic, nuclear, secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Matrix metalloproteinase 9 antibody is available for research use only.
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Description

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.

Application Notes

Optimal dilution of the Matrix metalloproteinase 9 antibody should be determined by the researcher.

Immunogen

Amino acids 603-614 were used as the immunogen for the Matrix metalloproteinase 9 antibody.

Storage

Store the Matrix metalloproteinase 9 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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