- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Mast Cell Tryptase Antibody / TPSAB1 [clone TPSAB1/1963] (V8138)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8138-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V8138-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V8138SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | TPSAB1/1963 |
| Purity | Protein G affinity chromatography |
| UniProt | Q15661 |
| Localization | Cytoplasmic, secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Mast Cell Tryptase antibody is available for research use only. |
|
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Mast Cell Tryptase antibody detects Tryptase alpha/beta-1, a mast cellâspecific serine protease encoded by the TPSAB1 gene. The UniProt recommended name is Tryptase alpha/beta-1 (TPSAB1). This enzyme is the predominant protein component of mast cell granules and serves as a key mediator of allergic inflammation, immune defense, and tissue remodeling.
Functionally, Mast Cell Tryptase antibody identifies a secreted protease that exists as a heparin-stabilized tetramer within mast cell granules. Upon activation, mast cells release tryptase along with histamine and cytokines, amplifying inflammatory responses. Extracellular tryptase cleaves matrix proteins, vasoactive peptides, and receptors such as PAR-2, triggering smooth muscle contraction, vascular leakage, and leukocyte recruitment. Through these actions, TPSAB1 plays important roles in both acute hypersensitivity and chronic inflammatory diseases.
The TPSAB1 gene is located on chromosome 16p13.3 and belongs to a cluster of closely related tryptase genes. It encodes multiple isoforms, including both alpha and beta tryptase variants, which differ slightly in enzymatic properties but share mast cellârestricted expression. Expression is regulated by cytokines and immunologic stimuli, linking mast cell activation to innate and adaptive immune responses.
Clinically, tryptase is used as a biomarker of mast cell activation and is elevated in conditions such as anaphylaxis, mastocytosis, and allergic asthma. Increased baseline levels are characteristic of hereditary alpha-tryptasemia, a genetic trait caused by extra TPSAB1 gene copies. Research using Mast Cell Tryptase antibody supports investigations of mast cell biology, protease signaling, and allergic inflammation.
Mast Cell Tryptase antibody is suitable for research use in detecting tryptase protein expression and studying mast cellâmediated pathways. NSJ Bioreagents provides this antibody reagent for applications in allergy, immunology, and inflammatory disease research.
Optimal dilution of the Mast Cell Tryptase antibody should be determined by the researcher.
A portion of amino acids 115-233 from the human protein was used as the immunogen for this Mast Cell Tryptase antibody.
Store the Mast Cell Tryptase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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