MARS1 Antibody / Methionyl-tRNA synthetase / MetRS (RQ7269)

Description

MARS1, also known as Methionyl-tRNA synthetase, is a key enzyme involved in the first step of protein synthesis. It catalyzes the attachment of methionine to its corresponding tRNA (tRNA^Met^), forming methionyl-tRNA, a critical substrate for translation initiation. MARS1 belongs to the class I aminoacyl-tRNA synthetase family and is essential for accurate codon recognition and efficient protein synthesis in both the cytoplasm and mitochondria.

Beyond its canonical role in translation, MARS1 has been implicated in several non-translational functions, including regulation of immune signaling, stress response, and cell survival pathways. Alterations in MARS1 expression or function have been associated with a range of human disorders, including interstitial lung and liver disease, neurodegeneration, and cancer. Due to its multifunctional role, MARS1 is of growing interest in studies of cellular metabolism, genetic disease, and therapeutic targeting.

The MARS1 antibody is a valuable research tool for detecting endogenous MARS1 in various model systems and tissue types. It is widely used in western blot, immunohistochemistry, and immunofluorescence applications to monitor MARS1 expression, localization, and potential dysregulation. With high specificity and sensitivity, the MARS1 antibody enables accurate analysis of translation machinery and supports research into disease mechanisms. Incorporating the MARS1 antibody into your workflow ensures robust performance for studies of protein biosynthesis and beyond.

Application Notes

Optimal dilution of the MARS1 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids R25-E887) was used as the immunogen for the MARS1 antibody.

Storage

After reconstitution, the MARS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.