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Home >> Antibodies >> MAPK8IP1 Antibody / JIP1

MAPK8IP1 Antibody / JIP1 (F55015)

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  Catalog No Formulation Size Price (USD)  
Image F55015-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F55015-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot testing of human 1) brain and 2) MCF7 cell lysate with MAPK8IP1 antibody. Expected molecular weight: 78-110 kDa.
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Western blot testing of human 1) brain and 2) MCF7 cell lysate with MAPK8IP1 antibody. Expected molecular weight: 78-110 kDa.
IHC testing of FFPE human brain tissue with MAPK8IP1 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Immunofluorescent staining of human MCF7 cells with MAPK8IP1 antibody (green) and DAPI nuclear stain (blue).
Flow cytometry testing of human MCF7 cells with MAPK8IP1 antibody; Blue=isotype control, Green= MAPK8IP1 antibody.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity purified
UniProt Q9UQF2
Localization Cytoplasmic, nuclear
Applications Immunofluorescence : 1:10-1:50
Flow cytometry : 1:10-1:50 (1x10e6 cells)
Immunohistochemistry (FFPE) : 1:50-1:100
Western blot : 1:500-1:1000
Limitations This MAPK8IP1 antibody is available for research use only.
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Description

JIP1 is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2.

Application Notes

The stated application concentrations are suggested starting points. Titration of the MAPK8IP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 470-498 from the human protein was used as the immunogen for the MAPK8IP1 antibody.

Storage

Aliquot the MAPK8IP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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