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Home >> Antibodies >> MAP4K3 Antibody / MEKKK3 / GLK

MAP4K3 Antibody / MEKKK3 / GLK [clone 219CT8.3.1] (F54521)

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  Catalog No Formulation Size Price (USD)  
Image F54521-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 429
Image
F54521-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 199
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IHC testing of FFPE human skeletal muscle tissue with MAP4K3 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
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IHC testing of FFPE human skeletal muscle tissue with MAP4K3 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Western blot testing of human 1) HepG2 and 2) MCF7 cell lysate with MAP4K3 antibody. Predicted molecular weight ~101 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype IgM, kappa
Clone Name 219CT8.3.1
Purity Purified
UniProt Q8IVH8
Applications Western Blot : 1:500-1:2000
Immunohistochemistry (FFPE) : 1:25
Limitations This MAP4K3 antibody is available for research use only.
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Description

This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).

Application Notes

The stated application concentrations are suggested starting points. Titration of the MAP4K3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Recombinant human protein was used as the immunogen for the MAP4K3 antibody.

Storage

Aliquot the MAP4K3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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