- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MAP2K1 Antibody / MEK1 (F54728)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
F54728-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 439 | |
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F54728-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 205 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity purified |
| UniProt | Q02750 |
| Localization | Cytoplasmic, nuclear |
| Applications | Immunohistochemistry (FFPE) : 1:25 Western Blot : 1:500-1:2000 |
| Limitations | This MAP2K1 antibody is available for research use only. |
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MAP2K1 Antibody / MEK1 recognizes mitogen-activated protein kinase kinase 1 (MAP2K1), more commonly known as MEK1, a dual-specificity protein kinase that serves as a central regulator of the RAF-MEK-ERK signaling cascade. Activated by RAF family kinases in response to growth factors, cytokines, and extracellular stimuli, MAP2K1 phosphorylates ERK1 and ERK2 to regulate cell proliferation, differentiation, survival, migration, and gene expression. Because MAP2K1 occupies a pivotal position within one of the most extensively studied intracellular signaling pathways, MAP2K1 Antibody / MEK1 is widely used to investigate cell signaling, developmental biology, oncology, and targeted therapeutic responses.
MAP2K1 belongs to the mitogen-activated protein kinase kinase family and exhibits remarkable substrate specificity, primarily phosphorylating ERK1 and ERK2 on both threonine and tyrosine residues required for their activation. Activated ERK proteins subsequently regulate numerous cytoplasmic and nuclear substrates involved in cell cycle progression, apoptosis, metabolism, cytoskeletal organization, and transcriptional control. Through these signaling events, MAP2K1 functions as a critical molecular switch that integrates extracellular signals with coordinated cellular responses required for tissue homeostasis and normal development.
Beyond regulating cell growth, MAP2K1 participates in angiogenesis, immune responses, neuronal development, stem cell maintenance, wound healing, and cellular adaptation to environmental stress. Because it acts immediately downstream of RAS and RAF proteins, MAP2K1 serves as a major signaling hub within the MAPK pathway, coordinating diverse biological processes across numerous tissues. Tight regulation of MEK1 activity is essential for maintaining normal physiology, while sustained activation promotes abnormal proliferation and disease progression.
Mutations affecting MAP2K1 and constitutive activation of the RAF-MEK-ERK pathway have been implicated in many human cancers as well as developmental disorders and inflammatory diseases. Consequently, MEK1 has become an important therapeutic target, with several clinically approved MEK inhibitors now used to treat cancers driven by aberrant MAPK signaling. NSJ Bioreagents' MAP2K1 Antibody / MEK1 supports investigations into MAPK signaling, ERK activation, cell proliferation, differentiation, oncogenic signaling, developmental biology, pharmacology, and targeted cancer therapeutics. Reliable detection of MAP2K1 enables researchers to study one of the central signaling kinases controlling cellular growth and environmental responses.
Learn more about the biological functions, applications, and validated products on our MEK1 Antibody / MAP Kinase Kinase Antibody page.
The stated application concentrations are suggested starting points. Titration of the MAP2K1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 200-227 from the human protein was used as the immunogen for the MAP2K1 antibody.
Aliquot the MAP2K1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
MAP2K1 antibody, MEK1 antibody, Mitogen-Activated Protein Kinase Kinase 1 antibody, MAPKK1 antibody, MKK1 antibody, ERK Activating Kinase antibody
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