- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MAFF Antibody / Transcription factor MafF (RQ8093)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ8093 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q9ULX9 |
| Localization | Nuclear |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This MAFF antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
MAFF antibody targets Transcription factor MafF (MAFF), a small Maf family basic leucine zipper transcription factor that regulates gene expression by forming homo- or heterodimers with other Maf proteins or CNC family transcription factors. MAFF localizes predominantly to the nucleus, where it binds Maf recognition elements in promoter and enhancer regions to modulate transcriptional programs linked to stress responses, redox balance, and cellular differentiation. As a small Maf protein, MAFF lacks a classical transactivation domain and instead functions as a context-dependent regulator through partner selection and DNA binding.
Functionally, MAFF participates in transcriptional regulation associated with oxidative stress, detoxification pathways, and metabolic homeostasis. By dimerizing with CNC proteins such as Nrf2, MAFF contributes to regulation of antioxidant response element-driven genes involved in cellular defense and redox control. MAFF expression is inducible under stress conditions, enabling cells to adapt transcriptional outputs in response to environmental and metabolic challenges. A MAFF antibody supports studies examining transcriptional regulation and stress-responsive signaling pathways.
MAFF also plays roles in developmental and tissue-specific gene regulation. Its expression has been reported in multiple tissues, with dynamic regulation depending on cellular state and differentiation stage. Through competitive dimerization, MAFF can either activate or repress target gene expression, providing fine control over transcriptional networks. These properties make MAFF a useful marker for investigating transcription factor interactions and regulatory balance within bZIP-mediated gene control systems.
From a biological and disease-relevance perspective, MAFF has been studied in the context of oxidative stress responses, inflammation, and cancer-associated transcriptional remodeling. Altered MAFF expression or dimerization balance can influence antioxidant capacity and cellular adaptation to stress, impacting tissue homeostasis and disease progression. Understanding MAFF regulation provides insight into how cells integrate environmental signals into transcriptional responses.
At the molecular level, MAFF is encoded by the MAFF gene and produces a protein of approximately 164 amino acids. The protein contains a conserved basic region for DNA binding and a leucine zipper domain for dimerization. Regulation of MAFF activity depends on expression level, dimerization partners, and cellular signaling context. A MAFF antibody supports research applications focused on transcriptional regulation, oxidative stress biology, and gene expression control, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the MAFF antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids M1-L37) was used as the immunogen for the MAFF antibody.
After reconstitution, the MAFF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
