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Home >> Antibodies >> Lymphotoxin beta Antibody / Ltb

Lymphotoxin beta Antibody / Ltb (RQ8506)

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  Catalog No Formulation Size Price (USD)  
Image RQ8506 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 439
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Flow cytometry testing of fixed and permeabilized mouse RAW264.7 cells with Lymphotoxin beta antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Lymphotoxin beta antibody.
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Flow cytometry testing of fixed and permeabilized mouse RAW264.7 cells with Lymphotoxin beta antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Lymphotoxin beta antibody.
Western blot testing of 1) rat PC-12, 2) mouse spleen, 3) mouse thymus and 4) mouse RAW264.7 cell lysate with Lymphotoxin beta antibody. Predicted molecular weight ~32 kDa.
Availability 1-3 days
Species Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P41155
Applications Western Blot : 0.5-1ug/ml
Flow Cytometry : 1-3ug/million cells
ELISA : 0.1-0.5ug/ml
Limitations This Lymphotoxin beta antibody is available for research use only.
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Description

Lymphotoxin-beta (LT-beta) also known as tumor necrosis factor C (TNF-C) is a protein that in humans is encoded by the LTB gene. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

Application Notes

Optimal dilution of the Lymphotoxin beta antibody should be determined by the researcher.

Immunogen

An E.coli-derived mouse recombinant protein (amino acids R68-G306) was used as the immunogen for the Lymphotoxin beta antibody.

Storage

After reconstitution, the Lymphotoxin beta antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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