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Home >> Antibodies >> LXRB Antibody

LXRB Antibody [clone LXRB/2731] (V8367)

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  Catalog No Formulation Size Price (USD)  
Image V8367-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V8367-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V8367SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free LXRB antibody (clone LXRB/2731) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free LXRB antibody (clone LXRB/2731) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2c, kappa
Clone Name LXRB/2731
Purity Protein G affinity chromatography
UniProt P55055
Localization Nuclear
Applications ELISA : order Ab without BSA for coating
Limitations This LXRB antibody is available for research use only.
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Description

The liver X receptors, LXRA (NR1H3) and LXRB (NR1H2) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements. LXRB can inhibit proliferation and induce apoptosis of cancer cells.

Application Notes

Optimal dilution of the LXRB antibody should be determined by the researcher.

Immunogen

Recombinant full-length human NR1H2/LXRB protein was used as the immunogen for the LXRB antibody.

Storage

Store the LXRB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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