- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Luteinizing Hormone Receptor Antibody LHCGR/7399 / LH Receptor Monoclonal Antibody [clone LHCGR/7399] (V4891)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4891-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4891-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4891SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2, kappa |
| Clone Name | LHCGR/7399 |
| Purity | Protein A/G affinity |
| UniProt | P22888 |
| Localization | Cytoplasm, Cell surface |
| Applications | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Limitations | This Luteinizing Hormone Receptor Antibody LHCGR/7399 / LH Receptor Monoclonal Antibody is available for research use only. |
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Luteinizing Hormone Receptor Antibody LHCGR/7399 / LH Receptor Monoclonal Antibody recognizes the luteinizing hormone/choriogonadotropin receptor, a G protein-coupled receptor encoded by the LHCGR gene. Also known as the LH receptor, hCG receptor, and lutropin-choriogonadotropic hormone receptor, LHCGR mediates the biological effects of luteinizing hormone (LH) and human chorionic gonadotropin (hCG). The receptor belongs to the glycoprotein hormone receptor family and contains a large extracellular ligand-binding domain, seven transmembrane segments, and an intracellular region involved in signal transduction.
LHCGR activation occurs when LH or hCG binds its extracellular domain, promoting conformational changes that stimulate intracellular G protein signaling. The receptor primarily couples to Gs proteins, activating adenylyl cyclase and increasing cyclic AMP production. This response stimulates protein kinase A-dependent pathways involved in steroidogenic enzyme regulation and hormone synthesis. Additional signaling mechanisms, including beta-arrestin recruitment and mitogen-activated protein kinase activation, contribute to receptor regulation, internalization, and context-dependent cellular responses.
In the ovary, LHCGR is expressed by theca cells and develops in granulosa cells as follicles mature. Receptor activation stimulates androgen synthesis in theca cells and contributes to the endocrine changes required for ovulation. The midcycle LH surge initiates oocyte maturation, follicular rupture, and luteinization. Following ovulation, LHCGR signaling supports progesterone production by the corpus luteum. During early pregnancy, placental hCG maintains corpus luteum function through the same receptor, supporting progesterone secretion until placental hormone production becomes sufficient.
In the testes, LHCGR is primarily expressed by Leydig cells, where LH stimulation promotes testosterone biosynthesis. Testosterone is essential for male reproductive development, androgen-dependent physiological functions, and maintenance of spermatogenesis. Genetic alterations affecting LHCGR activity can produce disorders of reproductive development and endocrine function. Loss-of-function variants may impair gonadal steroidogenesis, while activating variants can cause ligand-independent signaling and contribute to certain forms of precocious puberty.
Beyond its established gonadal functions, LHCGR expression has been investigated in reproductive tissues and selected malignancies, although the physiological significance of extragonadal expression remains context-dependent. Receptor abundance, cellular localization, and signaling regulation are important considerations in studies of reproductive endocrinology and hormone-responsive tissues. NSJ Bioreagents offers this Luteinizing Hormone Receptor Antibody for research examining gonadotropin receptor expression, steroidogenic regulation, reproductive development, and the molecular mechanisms connecting endocrine signals with cellular responses.
Explore our GPCR Antibodies for additional research tools targeting G protein-coupled receptors involved in endocrine signaling, reproductive regulation, and cellular signal transduction.
Optimal dilution of the Luteinizing Hormone Receptor Antibody LHCGR/7399 / LH Receptor Monoclonal Antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the Luteinizing Hormone Receptor antibody.
Aliquot the Luteinizing Hormone Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
LH Receptor antibody, hCG Receptor antibody, LHR antibody, Lutropin Receptor antibody, Choriogonadotropin Receptor antibody
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