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Home >> Antibodies >> LOX Antibody / Lysyl Oxidase

LOX Antibody / Lysyl Oxidase [clone 624CT23.7.3] (F40401)

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  Catalog No Formulation Size Price (USD)  
Image F40401-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F40401-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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LOX antibody western blot analysis in MDA-MB231 lysate. Expected molecular weight: ~47 kDa (unprocessed/unmodified), ~50 kDa (glycosylated), ~32 kDa (processed form).
LOX antibody western blot analysis in MDA-MB231 lysate. Expected molecular weight: ~47 kDa (unprocessed/unmodified), ~50 kDa (glycosylated), ~32 kDa (processed form).
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Rat, Pig
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b
Clone Name 624CT23.7.3
Purity Purified
UniProt P28300
Applications Western blot : 1:100-1:500
Limitations This LOX antibody is available for research use only.
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Description

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Application Notes

Titration of the LOX antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 234-260 from the human protein was used as the immunogen for this LOX antibody.

Storage

Aliquot the LOX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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