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Home >> Antibodies >> LIN7C Antibody / Protein lin-7 homolog C

LIN7C Antibody / Protein lin-7 homolog C (RQ8624)

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Image RQ8624 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 439
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IHC staining of FFPE human bladder urothelial carcinoma tissue with LIN7C antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human bladder urothelial carcinoma tissue with LIN7C antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human adrenal adenoma tissue with LIN7C antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human colorectal adenocarcinoma tissue with LIN7C antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE rat kidney tissue with LIN7C antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
Western blot testing of 1) human RT4 and 2) rat brain tissue lysate with LIN7C antibody. Predicted molecular weight ~22 kDa.
Flow cytometry testing of fixed and permeabilized human ThP-1 cells with LIN7C antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= LIN7C antibody.
Availability 1-3 days
Species Reactivity Human, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q9NUP9
Localization Cell membrane
Applications Western Blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 2-5ug/ml
Flow Cytometry : 1-3ug/million cells
ELISA : 0.1-0.5ug/ml
Limitations This LIN7C antibody is available for research use only.
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Description

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene. LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Application Notes

Optimal dilution of the LIN7C antibody should be determined by the researcher.

Immunogen

An E.coli-derived human recombinant protein (amino acids M1-A73) was used as the immunogen for the LIN7C antibody.

Storage

After reconstitution, the LIN7C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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