- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
LHR Antibody LHCGR/1417 / LH Receptor Monoclonal Antibody [clone LHCGR/1417] (V3356)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3356-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3356-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3356SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
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| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | LHCGR/1417 |
| Purity | Protein G affinity chromatography |
| UniProt | P22888 |
| Localization | Cytoplasmic, cell surface |
| Applications | ELISA (order BSA/sodium azide-free format for coating) Flow cytometry: 1-2ug/10^6 cells Western blot: 0.5-1ug/ml |
| Limitations | This LHR Antibody LHCGR/1417 / LH Receptor Monoclonal Antibody is available for research use only. |
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LHR Antibody LHCGR/1417 / LH Receptor Monoclonal Antibody recognizes the luteinizing hormone/choriogonadotropin receptor, a cell-surface glycoprotein encoded by the LHCGR gene. Also called the lutropin receptor or hCG receptor, LHCGR belongs to the glycoprotein hormone receptor family within the G protein-coupled receptor superfamily. Its structure includes a large extracellular domain responsible for hormone recognition, seven membrane-spanning segments, and intracellular regions that participate in signal transduction. The receptor responds to both luteinizing hormone (LH) and human chorionic gonadotropin (hCG), connecting endocrine signals with reproductive cellular functions.
Hormone binding activates intracellular signaling primarily through Gs proteins, which stimulate adenylyl cyclase and increase cyclic AMP production. The resulting activation of protein kinase A regulates proteins involved in steroid hormone biosynthesis. LHCGR can also engage additional signaling mechanisms, including beta-arrestin-dependent pathways and mitogen-activated protein kinase cascades. Receptor phosphorylation, internalization, and recycling influence the duration and intensity of hormonal responses.
In ovarian tissues, LHCGR is expressed by theca cells and becomes increasingly important in granulosa cells during follicular maturation. LH-dependent signaling promotes androgen production, supports follicular development, and initiates the processes leading to ovulation. Following the LH surge, receptor activation contributes to luteinization and progesterone synthesis by the corpus luteum. During early pregnancy, placental hCG acts through LHCGR to maintain luteal progesterone production until placental steroidogenesis becomes sufficient.
In the testes, LHCGR is expressed predominantly by Leydig cells, where LH stimulation promotes testosterone biosynthesis. Testosterone supports reproductive development, androgen-dependent physiological functions, and the hormonal environment required for spermatogenesis. Variants affecting receptor activity can disrupt reproductive endocrine regulation. Loss-of-function alterations may impair gonadal steroidogenesis, whereas activating variants can produce excessive receptor signaling and contribute to gonadotropin-independent precocious puberty.
LHCGR expression has also been investigated in selected hormone-responsive tissues and malignancies, although the significance of expression outside established gonadal cell populations remains under investigation. Understanding receptor abundance and regulation is important for studies of reproductive endocrinology, steroidogenic signaling, and hormone-dependent cellular responses. NSJ Bioreagents offers this LHR Antibody for research examining the molecular mechanisms connecting gonadotropin signaling with reproductive physiology.
Explore our Luteinizing Hormone Receptor Antibody LHCGR/7399 for additional research tools targeting LHCGR and investigating reproductive endocrine signaling and gonadal steroidogenesis.
Optimal dilution of the LHR Antibody LHCGR/1417 / LH Receptor Monoclonal Antibody should be determined by the researcher.
A partial recombinant protein from the N-terminal region of human Luteinizing hormone / Choriogonadotropin receptor was used as the immunogen for the LHR antibody.
Store the LHR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Luteinizing Hormone Receptor antibody, hCG Receptor antibody, Choriogonadotropin Receptor antibody, Lutropin Receptor antibody, LH/CG Receptor antibody
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