- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
LGALS3BP Antibody / Galectin-3-binding protein (FY13218)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13218 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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LGALS3BP antibody detects Galectin-3-binding protein, a secreted glycoprotein involved in cell adhesion, immune modulation, and tumor metastasis. The UniProt recommended name is Galectin-3-binding protein (LGALS3BP). Also known as 90K or Mac-2-binding protein, this multifunctional glycoprotein mediates extracellular interactions that influence immune cell communication, matrix remodeling, and viral infection processes.
Functionally, LGALS3BP antibody identifies a 585-amino-acid secreted protein characterized by a heavily glycosylated scavenger receptor cysteine-rich (SRCR)-like domain. LGALS3BP interacts with galectins, integrins, and extracellular matrix components such as fibronectin and laminin to facilitate cell adhesion and migration. It modulates immune signaling by promoting cytokine release, dendritic cell maturation, and macrophage activation. In the tumor microenvironment, LGALS3BP enhances metastatic potential by regulating cell-cell interactions and immune evasion mechanisms.
The LGALS3BP gene is located on chromosome 17q25.3 and is expressed in immune cells, epithelial tissues, and cancerous lesions. Its secretion increases in inflammatory conditions, viral infections, and malignancies, where it serves as a biomarker of immune activation and tumor progression.
Pathologically, elevated LGALS3BP levels have been associated with breast, prostate, and lung cancers, as well as HIV infection and autoimmune diseases. In cancer, high expression correlates with increased invasiveness and poor prognosis due to its roles in matrix remodeling and immune suppression. In infectious diseases, LGALS3BP can act as a host restriction factor that limits viral replication. Research using LGALS3BP antibody supports studies in cancer biology, immunology, and extracellular matrix signaling.
LGALS3BP antibody is validated for western blotting, immunohistochemistry, and ELISA to detect secreted glycoproteins. NSJ Bioreagents provides LGALS3BP antibody reagents optimized for research in tumor progression, immune signaling, and biomarker discovery.
Structurally, Galectin-3-binding protein forms disulfide-linked oligomers and contains multiple N-linked glycosylation sites critical for stability and receptor binding. Its SRCR-like domain mediates carbohydrate and protein interactions that underpin its diverse functional roles. This antibody enables analysis of LGALS3BPs involvement in cell communication, matrix adhesion, and immune regulation.
Optimal dilution of the LGALS3BP antibody should be determined by the researcher.
E.coli-derived human LGALS3BP recombinant protein (Position: H115-K508) was used as the immunogen for the LGALS3BP antibody.
After reconstitution, the LGALS3BP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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