Leptin Receptor Goat Polyclonal Antibody | LEPR

	Catalog No	Formulation	Size	Price (USD)
	R36253-100UG	0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide	100 ug	475
Formulation

Leptin Receptor Goat Polyclonal Antibody by WB in human brain. Western blot analysis of human brain lysate using Leptin Receptor Goat Polyclonal Antibody at 1 ug/ml. The experiment evaluates leptin receptor expression in neural tissue, where LEPR participates in metabolic and neuroendocrine signaling. The predicted molecular weights are approximately 125 kDa for the long receptor isoform and 100 kDa for the short isoform. This LEPR Goat Antibody targets a cytokine receptor involved in appetite regulation, energy homeostasis, and JAK/STAT signaling.

Leptin Receptor Goat Polyclonal Antibody by WB in rodent brain. Western blot analysis of mouse and rat brain lysates using Leptin Receptor Goat Polyclonal Antibody at 0.1 ug/ml. Lane 1: mouse brain; lane 2: rat brain. The predicted molecular weights of the leptin receptor isoforms are approximately 125 kDa for the long form and 100 kDa for the short form. This LEPR Goat Antibody demonstrates experimental reactivity with rodent brain samples and targets a receptor involved in metabolic regulation and intracellular signaling.

Leptin Receptor Goat Polyclonal Antibody by IHC in human heart. Immunohistochemistry of FFPE human heart tissue using Leptin Receptor Goat Polyclonal Antibody at 4 ug/ml. Heat-induced epitope retrieval was performed by steaming tissue sections in citrate buffer, pH 6.0, followed by alkaline phosphatase-based detection. The experiment evaluates leptin receptor expression in cardiac tissue, where leptin signaling has been investigated in relation to cardiovascular physiology and cellular metabolism. This LEPR Goat Antibody recognizes a cytokine receptor associated with JAK/STAT signaling.

Leptin Receptor Goat Polyclonal Antibody by IHC in human liver. Immunohistochemistry of FFPE human liver tissue using Leptin Receptor Goat Polyclonal Antibody at 4 ug/ml. Heat-induced epitope retrieval was performed by steaming tissue sections in citrate buffer, pH 6.0, followed by alkaline phosphatase-based detection. LEPR participates in hormonal signaling pathways that influence metabolic regulation and energy homeostasis. This LEPR Goat Antibody targets a cytokine receptor involved in leptin-dependent signaling and peripheral metabolic responses.

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Leptin Receptor Goat Polyclonal Antibody by WB in human brain. Western blot analysis of human brain lysate using Leptin Receptor Goat Polyclonal Antibody at 1 ug/ml. The experiment evaluates leptin receptor expression in neural tissue, where LEPR participates in metabolic and neuroendocrine signaling. The predicted molecular weights are approximately 125 kDa for the long receptor isoform and 100 kDa for the short isoform. This LEPR Goat Antibody targets a cytokine receptor involved in appetite regulation, energy homeostasis, and JAK/STAT signaling.

Leptin Receptor Goat Polyclonal Antibody by WB in rodent brain. Western blot analysis of mouse and rat brain lysates using Leptin Receptor Goat Polyclonal Antibody at 0.1 ug/ml. Lane 1: mouse brain; lane 2: rat brain. The predicted molecular weights of the leptin receptor isoforms are approximately 125 kDa for the long form and 100 kDa for the short form. This LEPR Goat Antibody demonstrates experimental reactivity with rodent brain samples and targets a receptor involved in metabolic regulation and intracellular signaling.

Leptin Receptor Goat Polyclonal Antibody by IHC in human heart. Immunohistochemistry of FFPE human heart tissue using Leptin Receptor Goat Polyclonal Antibody at 4 ug/ml. Heat-induced epitope retrieval was performed by steaming tissue sections in citrate buffer, pH 6.0, followed by alkaline phosphatase-based detection. The experiment evaluates leptin receptor expression in cardiac tissue, where leptin signaling has been investigated in relation to cardiovascular physiology and cellular metabolism. This LEPR Goat Antibody recognizes a cytokine receptor associated with JAK/STAT signaling.

Leptin Receptor Goat Polyclonal Antibody by IHC in human liver. Immunohistochemistry of FFPE human liver tissue using Leptin Receptor Goat Polyclonal Antibody at 4 ug/ml. Heat-induced epitope retrieval was performed by steaming tissue sections in citrate buffer, pH 6.0, followed by alkaline phosphatase-based detection. LEPR participates in hormonal signaling pathways that influence metabolic regulation and energy homeostasis. This LEPR Goat Antibody targets a cytokine receptor involved in leptin-dependent signaling and peripheral metabolic responses.

Species Reactivity	Human
Predicted Reactivity	Dog
Format	Antigen affinity purified
Host	Goat
Clonality	Polyclonal (goat origin)
Isotype	Goat Ig
Purity	Antigen affinity
Gene ID	3953
Applications	Western Blot : 1-3ug/ml IHC (FFPE) : 4ug/ml ELISA (peptide) LOD : 1:16000
Limitations	This Leptin Receptor Goat Polyclonal Antibody / LEPR Goat Antibody is available for research use only.
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Description

Leptin Receptor Goat Polyclonal Antibody recognizes leptin receptor (LEPR), also known as Ob-R or CD295, a transmembrane protein that mediates the physiological effects of the hormone leptin. Produced primarily by adipocytes, leptin communicates information about energy stores to the central nervous system and peripheral tissues. LEPR belongs to the class I cytokine receptor family and participates in regulating appetite, energy expenditure, glucose metabolism, and endocrine function. The LEPR Goat Antibody targets a receptor that connects nutritional status with intracellular signaling and metabolic homeostasis.

The human LEPR gene is located on chromosome 1p31.3 and produces multiple receptor isoforms through alternative RNA splicing. These isoforms share an extracellular leptin-binding region but differ in their intracellular domains. The long isoform, LEPRb or Ob-Rb, contains an extended cytoplasmic region required for efficient activation of major downstream signaling pathways. Shorter isoforms participate in leptin transport and other receptor-associated processes. LEPR lacks intrinsic kinase activity and instead relies on associated signaling proteins to transmit extracellular signals.

Leptin binding promotes activation of receptor-associated Janus kinase 2 (JAK2), initiating phosphorylation events that recruit intracellular signaling proteins. STAT3 is a principal downstream mediator involved in regulating transcriptional programs associated with appetite suppression and energy balance. LEPR signaling can also influence STAT5, PI3K/AKT, and MAPK pathways, depending on cellular context. Negative regulators, including SOCS3 and PTP1B, help control the intensity and duration of receptor signaling. The LEPR Goat Antibody is relevant to research examining these interconnected regulatory mechanisms.

LEPR activity is particularly important in hypothalamic neuronal circuits that coordinate feeding behavior, energy expenditure, and neuroendocrine responses. The receptor also contributes to reproductive physiology, immune regulation, and peripheral metabolic function. Genetic defects affecting leptin receptor signaling can cause severe early-onset obesity and associated endocrine abnormalities. Reduced cellular responsiveness to leptin, commonly described as leptin resistance, is investigated in obesity, insulin resistance, and metabolic disease research.

Studies involving LEPR contribute to understanding hormonal regulation, metabolic homeostasis, cytokine receptor signaling, and communication between adipose tissue and other organs. The receptor provides an important connection between energy balance and JAK/STAT-mediated cellular responses. NSJ Bioreagents offers antibodies targeting proteins involved in metabolism and signal transduction. A Leptin Receptor Goat Polyclonal Antibody provides a research tool for investigating leptin receptor expression, receptor isoforms, and mechanisms involved in metabolic and endocrine regulation.

For an alternative monoclonal antibody targeting this receptor, see our LEPR Antibody.

Application Notes

Optimal dilution of the Leptin Receptor Goat Polyclonal Antibody / LEPR Goat Antibody should be determined by the researcher.

Immunogen

Amino acids TQDDIEKHQSDAG were used as the immunogen for this Leptin Receptor Goat Polyclonal Antibody.

Storage

Aliquot and store the Leptin Receptor Goat Polyclonal Antibody at -20oC.

Alternate Names

LEPR Goat antibody, Ob-R Goat antibody, CD295 Goat antibody, Leptin Receptor Polyclonal antibody, Leptin Binding Receptor antibody, Leptin Receptor Protein antibody

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Leptin Receptor Goat Polyclonal Antibody / LEPR Goat Antibody (R36253)

Description

Application Notes

Immunogen

Storage

Alternate Names

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Area of Research

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Protocols

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NSJ Bioreagents