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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Leptin Antibody / Metabolic Signaling Hormone Antibody (RQ4442)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ4442 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| UniProt | P41160 |
| Localization | Secreted |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml ELISA (Capture Of Mouse Recombinant Protein) : 1-5ug/ml |
| Limitations | This Leptin Antibody / Metabolic Signaling Hormone Antibody is available for research use only. |
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Leptin (LEP) is a secreted peptide hormone encoded by the LEP gene that functions as a central regulator of appetite, energy expenditure, metabolic homeostasis, and neuroendocrine signaling. Leptin Antibody / Metabolic Signaling Hormone Antibody is useful for investigating adipokine-mediated signaling pathways involved in obesity, insulin sensitivity, inflammatory regulation, and endocrine communication. Leptin antibody, also referred to as LEP antibody, Obesity factor antibody, Adipokine antibody, or Satiety hormone antibody in the literature, recognizes a key adipocyte-derived signaling molecule that communicates systemic energy status to the hypothalamus and peripheral tissues. This rabbit polyclonal antibody supports research applications focused on metabolic regulation, adipose tissue biology, and obesity-associated signaling networks.
Leptin is primarily produced by white adipose tissue and circulates as an endocrine hormone that regulates appetite suppression and energy expenditure through activation of the leptin receptor (LEPR/Ob-R) in hypothalamic neurons. Binding of leptin to LEPR activates downstream signaling cascades including JAK2-STAT3, PI3K-AKT, MAPK/ERK, and AMPK-associated pathways involved in feeding behavior, glucose metabolism, lipid utilization, and neuroendocrine control. Physiologically, leptin serves as an important feedback mediator linking adipose tissue mass to central nervous system regulation of hunger and metabolic balance.
In addition to its established role in body weight regulation, leptin participates in immune modulation, angiogenesis, reproductive biology, wound healing, and inflammatory signaling. Elevated circulating leptin levels are frequently associated with obesity, metabolic syndrome, insulin resistance, type 2 diabetes mellitus, cardiovascular disease, and chronic low-grade inflammation. Leptin additionally influences macrophage activation, T cell responses, cytokine production, and adipose tissue inflammatory remodeling, supporting its classification as both a metabolic and immunomodulatory signaling factor.
Leptin signaling has also been implicated in cancer biology, particularly in malignancies associated with obesity-related metabolic dysregulation. Increased leptin pathway activity has been linked to tumor proliferation, angiogenesis, epithelial-mesenchymal transition, and microenvironment remodeling in breast cancer, colorectal cancer, ovarian cancer, pancreatic cancer, and hepatocellular carcinoma. Because leptin integrates endocrine, metabolic, inflammatory, and proliferative signaling networks, LEP-directed antibodies are widely used in obesity research, endocrine biology, cancer metabolism, and translational metabolic disease studies.
At the cellular level, leptin is synthesized within secretory compartments of adipocytes and other leptin-producing cells before extracellular release into circulation. Immunohistochemical and immunofluorescence studies commonly demonstrate cytoplasmic staining patterns consistent with peptide hormone synthesis and secretory pathway localization. In tissue sections, leptin expression may be observed in adipocytes, epithelial cells, placental tissues, inflammatory microenvironments, and selected tumor cell populations depending on physiologic state and disease context. This rabbit polyclonal Leptin antibody provides a useful approach for studying metabolic signaling hormone biology, adipokine-associated communication pathways, and systemic energy regulation mechanisms.
Additional obesity and endocrine signaling research antibodies are available in our Metabolism Antibodies page.
Optimal dilution of the Leptin Antibody / Metabolic Signaling Hormone Antibody should be determined by the researcher.
Mouse Leptin recombinant protein (amino acids V22-C167) was used as the immunogen for the Leptin antibody.
After reconstitution, the Leptin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
LEP antibody, Obesity factor antibody, Adipokine antibody, Satiety hormone antibody, Adipocyte-derived hormone antibody
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