- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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LAMP2 Antibody / CD107b Antibody, clone 157CT16.6.6, recognizes Lysosome Associated Membrane Protein 2 (LAMP2), a highly glycosylated lysosomal membrane protein that is essential for lysosome integrity, intracellular protein degradation, and autophagy. The LAMP2 gene produces three major splice variants, LAMP2A, LAMP2B, and LAMP2C, which share a common luminal domain but possess distinct transmembrane and cytoplasmic regions that confer specialized biological functions. Antibodies recognizing the shared regions of LAMP2 detect all major isoforms, making them valuable tools for investigating lysosomal biology, membrane trafficking, and protein homeostasis across a broad range of tissues.
LAMP2 is one of the most abundant proteins of the lysosomal membrane, where its heavily glycosylated luminal domain protects the membrane from degradation by lysosomal hydrolases. Beyond this structural role, LAMP2 participates in lysosome maturation, autophagosome-lysosome fusion, endosomal trafficking, and intracellular recycling pathways. Individual isoforms also perform specialized functions. LAMP2A serves as the receptor for chaperone-mediated autophagy, LAMP2B is important for lysosomal function in muscle and cardiac tissue, and LAMP2C has been implicated in lysosomal nucleic acid transport. Together, these activities make LAMP2 a central regulator of cellular quality control and metabolic homeostasis.
LAMP2 is also designated CD107b, the cluster of differentiation name widely used in immunology. CD107b is expressed on the surface of cytotoxic T lymphocytes, natural killer cells, macrophages, and other immune cells during lysosomal exocytosis and degranulation. Consequently, CD107b serves as a well-established functional marker for immune cell activation, cytotoxic responses, and lysosome-dependent secretion, particularly in flow cytometry assays. Altered LAMP2 expression has additionally been associated with cancer, neurodegenerative disorders, inflammatory diseases, and Danon disease, a lysosomal storage disorder caused by pathogenic variants in the LAMP2 gene. Because of these diverse biological roles, LAMP2 remains an important target for studies of lysosomal dysfunction, autophagy, and immune regulation.
A LAMP2 Antibody is a valuable research tool for investigating lysosome biology, autophagy, intracellular trafficking, immune cell activation, and diseases involving lysosomal dysfunction.
For research focused specifically on chaperone-mediated autophagy, see our LAMP2A Antibody / Chaperone-Mediated Autophagy Receptor Antibody page.
The stated application concentrations are suggested starting amounts. Titration of the LAMP2 Antibody / CD107b Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This LAMP2 antibody was produced from a mouse immunized with LAMP2 recombinant protein.
Store at 4oC for up to one month. For long term, aliquot the LAMP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
LAMP2 antibody, CD107b antibody, Lysosome Associated Membrane Protein 2 antibody, Lysosome Associated Membrane Glycoprotein 2 antibody
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