- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Lamin B2 Antibody / LMNB2 (FY12337)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12337 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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The Lamin B2 antibody targets lamin B2, an essential component of the nuclear lamina. Lamins are type V intermediate filament proteins that provide structural support to the nuclear envelope and participate in chromatin organization, DNA replication, transcription, and nuclear stability. Lamin B2, encoded by the LMNB2 gene, localizes to the inner nuclear membrane where it forms a filamentous meshwork underlying the nuclear envelope. This protein is crucial for maintaining nuclear shape, ensuring proper chromosome segregation during mitosis, and anchoring chromatin domains. The Lamin B2 antibody allows researchers to investigate the abundance, localization, and regulatory functions of this protein in diverse biological contexts.
Lamin B2 is expressed in most somatic tissues and plays particularly important roles in proliferating cells. Mutations in LMNB2 have been associated with neurological disorders such as progressive myoclonus epilepsy, underscoring the importance of Lamin B2 for brain development and function. Studies have also implicated changes in lamin expression in processes such as aging, cancer, and viral infection, making antibodies against these proteins highly valuable for mechanistic investigations. The Lamin B2 antibody provides a reliable means of probing nuclear envelope biology and identifying changes that accompany disease progression.
In experimental applications, the Lamin B2 antibody has broad utility. Western blotting can reveal protein levels and detect shifts in size due to post-translational modifications. Immunofluorescence microscopy allows visualization of nuclear lamina organization and potential defects in nuclear envelope integrity. Immunohistochemistry enables tissue-level assessment of lamin expression, which may vary between normal and diseased tissues. Given lamin involvement in DNA replication and repair, the Lamin B2 antibody is also relevant in studies of genomic stability and cellular responses to stress. These uses highlight the versatility of the reagent for both basic and translational research.
The structural role of lamin proteins makes them targets of interest in cancer research. Altered lamin expression has been linked to changes in nuclear morphology, a hallmark of many tumor cells. Lamin B2 dysregulation could influence tumor progression by affecting nuclear stiffness, gene expression, and mechanotransduction. NSJ Bioreagents provides the Lamin B2 antibody as a high-quality research tool to support studies of lamin structure, nuclear function, and disease relevance. By enabling detailed characterization of Lamin B2 expression and localization, this antibody helps advance understanding of nuclear architecture and its contribution to health and pathology.
Optimal dilution of the Lamin B2 antibody should be determined by the researcher.
E.coli-derived human Lamin B2/LMNB2 recombinant protein (Position: L128-E585) was used as the immunogen for the Lamin B2 antibody.
After reconstitution, the Lamin B2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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