- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Lamin B1 antibody is a key reagent for studying nuclear structure, chromatin organization, and cellular aging. The encoded protein, LMNB1, is a member of the intermediate filament family that forms part of the nuclear lamina, a dense fibrous network underlying the inner nuclear membrane. Lamin B1 provides structural support to the nucleus and plays a central role in maintaining nuclear shape, organizing chromatin, and regulating gene expression. Its functions extend beyond mechanical stability, influencing processes such as DNA replication, transcriptional regulation, and cell cycle progression.
LMNB1 interacts with chromatin-associated proteins and transcriptional regulators, anchoring specific genomic regions to the nuclear periphery. Through these interactions, lamin B1 helps establish functional nuclear domains that modulate gene expression. The balance of lamin proteins, including lamin B1, is critical for normal nuclear architecture. Alterations in LMNB1 levels disrupt chromatin organization and can trigger cellular senescence, highlighting its importance in development and aging.
Clinical studies have connected lamin B1 dysregulation to disease. Overexpression of LMNB1 is associated with autosomal dominant leukodystrophy (ADLD), a neurodegenerative disorder marked by abnormal myelin loss in the central nervous system. In cancer biology, altered expression of lamin B1 has been linked to tumor progression, where changes in nuclear structure affect proliferation and invasion. These findings emphasize the role of lamin B1 not only as a structural protein but also as a factor influencing disease states.
At the molecular level, lamin B1 assembles into higher-order filaments that integrate with lamin A/C and other nuclear envelope proteins. This network provides both mechanical resilience and dynamic regulation of nuclear processes. Studies suggest that lamin B1 also participates in DNA damage responses, contributing to genome stability. Its multifunctional roles make LMNB1 an important target for research in cell biology, neuroscience, and oncology.
The Lamin B1 antibody is commonly employed in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to evaluate expression levels, nuclear localization, and disease-related changes. These applications support research into nuclear organization, senescence, and disease pathology. For investigators studying nuclear structure, chromatin regulation, or neurodegenerative disorders, the Lamin B1 antibody is a reliable detection tool. NSJ Bioreagents offers validated antibodies that provide accuracy and reproducibility in advanced molecular research.
The stated application concentrations are suggested starting points. Titration of the Lamin B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 570-586 (FHQQGTPRASNRSCAIM-human) were used as the immunogen for this Lamin B1 antibody.
After reconstitution, the Lamin B1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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