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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Lamin B1 Antibody / Nuclear Envelope Marker Antibody detects LMNB1, a major structural component of the nuclear lamina located beneath the inner nuclear membrane. Lamin B1 belongs to the type V intermediate filament protein family and forms a filamentous network that provides mechanical support to the nucleus. This nuclear scaffold helps regulate nuclear shape, chromatin organization, DNA replication and gene expression. Because of its stable localization at the nuclear periphery, Lamin B1 is widely studied as a marker of nuclear envelope structure and nuclear organization.
Lamin B1 plays an important role in maintaining nuclear architecture and coordinating interactions between chromatin and the nuclear envelope. The nuclear lamina influences genome organization by anchoring specific chromosomal regions and regulating access to transcriptional machinery. Changes in Lamin B1 expression and distribution can affect nuclear stability, cellular function and responses to stress. Lamin B1 Antibody is commonly used by researchers studying nuclear morphology, nuclear membrane biology, chromatin organization and cellular structural regulation.
Research involving LMNB1 spans multiple areas including cell biology, aging, cancer biology and neurological research. Reduced Lamin B1 expression is frequently studied as a feature associated with cellular senescence, while altered nuclear lamina organization has been connected with changes in gene regulation and disease-associated cellular states. LMNB1 duplication and abnormal Lamin B1 regulation are also investigated in neurological disorders, highlighting the importance of nuclear envelope integrity in specialized cell types.
Lamin B1 is frequently analyzed alongside other nuclear markers to evaluate nuclear organization, cell identity and structural changes during biological processes. Studies of nuclear lamina proteins provide insight into how nuclear architecture influences genome function, cell division and cellular aging pathways. As a core nuclear envelope protein, Lamin B1 remains an important target for understanding relationships between nuclear structure and cellular regulation.
Lamin B1 Antibody applications include detection of LMNB1 expression, localization and regulation in biological samples using techniques such as Western blot, immunohistochemistry, immunofluorescence and related protein analysis methods. NSJ Bioreagents provides Lamin B1 Antibody / Nuclear Envelope Marker Antibody for researchers studying nuclear envelope biology, chromatin organization, cellular senescence and nuclear structure regulation.
Lamin B1 Antibody detects a nuclear lamina protein involved in nuclear envelope structure, chromatin organization and cellular regulation, making it a useful marker for research areas featured in our Cell Biology Antibodies page.
The stated application concentrations are suggested starting points. Titration of the Lamin B1 Antibody / Nuclear Envelope Marker Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 570-586 (FHQQGTPRASNRSCAIM-human) were used as the immunogen for this Lamin B1 antibody.
After reconstitution, the Lamin B1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
LMNB1 Antibody, Lamin-B1 Antibody, Nuclear Lamin B1 Antibody, Nuclear Lamina Protein Antibody, Nuclear Envelope Protein Antibody, Senescence Marker Antibody
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