- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Ku80 Antibody / DNA-PK Complex Interaction Antibody [clone XRCC5/7318] (V9741)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9741-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9741-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9741SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | XRCC5/7318 |
| Purity | Protein A/G affinity |
| UniProt | P13010 |
| Localization | Nucleus |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This XRCC5 antibody is available for research use only. |
|
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Ku80 (XRCC5) is a critical component of the DNA-dependent protein kinase (DNA-PK) complex, a multi-protein assembly that plays a central role in the repair of DNA double-strand breaks. Ku80 Antibody is uniquely positioned for studies focused on protein complex interactions, enabling detection of Ku80 within the DNA-PK complex and providing insight into how repair machinery is assembled and regulated. As part of the Ku heterodimer with Ku70 (XRCC6), Ku80 binds DNA ends and facilitates recruitment of DNA-PKcs, forming an active repair complex.
Ku80 Antibody is uniquely positioned for investigating protein-protein interactions within DNA repair pathways, where Ku80 functions as a structural platform for assembly of repair components. Ku80 antibody, also known as XRCC5 antibody, detects a nuclear protein that directly interacts with DNA-PKcs and other repair factors, enabling activation of kinase activity required for efficient DNA repair. This interaction is essential for linking DNA damage recognition to downstream enzymatic processing.
The DNA-PK complex represents a critical step in the non-homologous end joining pathway, integrating DNA binding with catalytic activity. Ku80 plays a central role in stabilizing this complex and coordinating interactions between multiple proteins involved in repair. Detection of Ku80 allows researchers to study how these complexes form, how they are regulated, and how they respond to DNA damage.
In experimental systems, Ku80 can be used to examine the dynamics of protein complex assembly and disassembly, particularly in response to genotoxic stress. Changes in Ku80 interaction with DNA-PKcs or other partners can reflect alterations in repair efficiency or signaling activity. This makes Ku80 a valuable marker for studies focused on protein interaction networks and repair complex regulation.
As a member of the DNA repair protein family, Ku80 integrates structural DNA binding with recruitment of enzymatic components. Its involvement in DNA-PK complex formation makes it particularly relevant for understanding how repair processes are coordinated at the molecular level. Ku80 Antibody provides a targeted tool for analyzing protein interactions and DNA repair complex assembly.
Optimal dilution of the Ku80 Antibody / DNA-PK Complex Interaction Antibody should be determined by the researcher.
A portion of amino acids 300-500 was used as the immunogen for the Ku80 Antibody / DNA-PK Complex Interaction Antibody.
Aliquot the XRCC5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
XRCC5 antibody, Ku80 DNA-PK antibody, Ku80 protein interaction antibody, XRCC5 DNA repair complex antibody, Ku80 binding partner antibody
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