- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Ku80 Antibody / Cancer Biomarker Antibody [clone XRCC5/7317] (V9740)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9740-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V9740-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V9740SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | XRCC5/7317 |
| Purity | Protein A/G affinity |
| UniProt | P13010 |
| Localization | Nucleus |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Ku80 antibody is available for research use only. |
|
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Ku80 (XRCC5) is a DNA repair protein that is widely recognized for its involvement in tumor biology, where it contributes to cancer cell survival, genomic instability, and resistance to therapy. Ku80 Antibody is uniquely positioned for studies focused on cancer biomarkers, enabling detection of a DNA repair protein that plays a central role in how tumor cells respond to genotoxic stress. As part of the Ku heterodimer with Ku70 (XRCC6), Ku80 facilitates repair of DNA double-strand breaks, a process that cancer cells often exploit to maintain viability under conditions of high DNA damage.
Ku80 Antibody is uniquely positioned for investigating tumor-associated DNA repair mechanisms and their contribution to disease progression. Ku80 antibody, also known as XRCC5 antibody, detects a nuclear protein that is frequently upregulated in malignant tissues and associated with increased DNA repair capacity. This enhanced repair capability allows tumor cells to survive exposure to radiation and DNA-damaging chemotherapeutic agents, making Ku80 a key factor in therapeutic resistance.
In many cancer types, elevated Ku80 expression correlates with aggressive tumor behavior, increased proliferation, and poor clinical outcomes. Its role in maintaining genome integrity under stress conditions makes it a valuable marker for assessing tumor resilience and adaptability. Detection of Ku80 can provide insight into how cancer cells balance DNA damage accumulation with repair processes, and how these mechanisms influence treatment response.
Ku80 is also relevant in studies examining tumor heterogeneity, where differences in DNA repair capacity can exist within a single tumor population. Monitoring Ku80 expression across different cell populations can reveal variations in repair efficiency and susceptibility to therapy. This makes it a useful tool for investigating mechanisms of tumor evolution and resistance.
As a member of the DNA repair protein family, Ku80 interacts with DNA-dependent protein kinase and other repair components to sustain tumor cell survival. Its role in enabling repair under stress conditions makes it particularly important in oncology research. Ku80 Antibody provides a focused tool for studying cancer-associated DNA repair processes, tumor progression, and mechanisms of resistance to treatment.
Optimal dilution of the Ku80 antibody should be determined by the researcher.
A portion of amino acids 300-500 was used as the immunogen for the Ku80 Antibody / Cancer Biomarker Antibody.
Aliquot the Ku80 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
XRCC5 antibody, Ku80 cancer marker antibody, Ku80 tumor biomarker antibody, XRCC5 oncology antibody, Ku80 cancer research antibody
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