- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Ku80 Antibody / Genome Stability Maintenance Antibody [clone FAE-24] (RQ5399)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5399 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | FAE-24 |
| Purity | Affinity purified |
| UniProt | P13010 |
| Applications | Western Blot : 1:5000-1:10000 |
| Limitations | This Ku80 antibody is available for research use only. |
|
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Ku80 (XRCC5) is a fundamental protein required for maintaining genome stability by ensuring accurate repair of DNA double-strand breaks and preservation of chromosomal integrity. Ku80 Antibody is uniquely positioned for studies focused on genome stability maintenance, where detection of repair proteins provides insight into how cells protect their genetic material over time. As part of the Ku heterodimer with Ku70 (XRCC6), Ku80 binds DNA ends and promotes efficient repair through the non-homologous end joining pathway.
Ku80 Antibody is uniquely positioned for investigating long-term genome maintenance mechanisms, where the balance between DNA damage and repair determines cellular health and function. Ku80 antibody, also known as XRCC5 antibody, detects a nuclear protein that plays a critical role in preventing accumulation of DNA damage and chromosomal abnormalities. Its activity is essential for maintaining stable genomes during replication and in response to environmental stress.
Loss or dysfunction of Ku80 has been associated with increased genomic instability, accumulation of DNA breaks, and susceptibility to disease, including cancer. Conversely, proper expression and function of Ku80 contribute to cellular resilience and long-term maintenance of genome integrity. This makes Ku80 a valuable marker for studying how cells prevent genetic deterioration and preserve chromosomal structure.
Ku80 is also relevant in studies of aging and disease, where accumulation of DNA damage over time can lead to functional decline. Monitoring Ku80 expression and activity provides insight into how effectively cells maintain genome stability under chronic stress conditions. This makes it useful for research into age-related genomic instability and disease progression.
As a member of the DNA repair protein family, Ku80 functions in coordination with DNA-dependent protein kinase and other repair components to preserve genome integrity. Its role extends beyond immediate repair events to long-term maintenance of chromosomal stability. Ku80 Antibody provides a focused tool for studying genome stability, DNA repair efficiency, and the biological consequences of genomic instability.
Optimal dilution of the Ku80 Antibody / Genome Stability Maintenance Antibody should be determined by the researcher.
A synthetic peptide specific to human Ku80 / XRCC5 was used as the immunogen for the Ku80 Antibody / Genome Stability Maintenance Antibody.
Store the Ku80 antibody at -20oC.
XRCC5 antibody, Ku80 genome stability antibody, Ku80 genomic integrity antibody, XRCC5 stability marker antibody, Ku80 DNA maintenance antibody
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