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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Krueppel-like Factor 4 Antibody / KLF4 Antibody recognizes KLF4, a zinc finger transcription factor that regulates epithelial differentiation, stem cell maintenance, proliferation, and cellular homeostasis. Encoded by the KLF4 gene, this transcription factor binds GC-rich DNA sequences to activate or repress target genes involved in cell cycle progression, differentiation, apoptosis, and tissue development. Through context-dependent transcriptional regulation, KLF4 helps coordinate the balance between self-renewal and differentiation in numerous tissues. Krueppel-like Factor 4 Antibody is widely used to investigate transcriptional control and epithelial biology.
KLF4 is highly expressed in stratified epithelia and the gastrointestinal tract, where it promotes terminal differentiation and maintains tissue integrity. The protein also contributes to vascular biology, immune regulation, and responses to cellular stress. In stem cell research, KLF4 is recognized as one of the four Yamanaka factors capable of reprogramming differentiated somatic cells into induced pluripotent stem cells alongside OCT4, SOX2, and c-MYC. These functions have made KLF4 an important model for understanding developmental plasticity, lineage specification, and regenerative medicine.
Abnormal KLF4 expression has been reported in numerous malignancies, including colorectal, breast, gastric, skin, and head and neck cancers. Depending on cellular context, KLF4 can exhibit tumor suppressive or oncogenic properties by influencing proliferation, epithelial-to-mesenchymal transition, stemness, differentiation, and therapeutic response. Beyond oncology, altered KLF4 activity has been implicated in inflammatory disorders, cardiovascular disease, wound healing, and tissue regeneration. Krueppel-like Factor 4 Antibody is therefore valuable for investigations into developmental biology, cancer progression, and regenerative medicine.
KLF4 is routinely analyzed by Western blotting, immunohistochemistry, immunofluorescence, immunoprecipitation, flow cytometry, and chromatin-associated assays to examine protein expression, nuclear localization, and transcriptional regulation. A Krueppel-like Factor 4 Antibody is an important research tool for investigating epithelial differentiation, stem cell biology, pluripotency, transcriptional regulation, and cellular reprogramming.
Learn more about KLF4 biology and its role as a stem cell-associated transcription factor by visiting our KLF4 Antibody / Stem Cell Transcription Factor Antibody page.
Optimal dilution of the Krueppel-like Factor 4 Antibody / KLF4 Antibody should be determined by the researcher.
Recombinant human protein (amino acids M1-H389) was used as the immunogen for the Krueppel-like factor 4 antibody.
After reconstitution, the Krueppel-like factor 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Krueppel-like Factor 4 antibody, KLF4 antibody, Gut-Enriched Krueppel-Like Factor antibody, EZF antibody
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