- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
KRT6A Antibody / Keratin 6A [clone MSVA-606R] (V5926)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5926-100UG | Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5926-20UG | Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 |
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| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MSVA-606R |
| UniProt | P02538 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1:100-1:200 |
| Limitations | This KRT6A/Keratin 6A antibody is available for research use only. |
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KRT6A antibody targets Keratin 6A, a type II cytoskeletal keratin encoded by the KRT6A gene and also widely referred to as cytokeratin 6A and CK6A in the literature. Keratin 6A is a member of the intermediate filament protein family and plays a central structural role in epithelial cells that experience mechanical stress, rapid turnover, or regenerative demand. It is normally expressed at low levels in most stratified epithelia but becomes strongly upregulated during epithelial activation, wound repair, and hyperproliferative states.
Keratin 6A forms obligate heteropolymers with type I keratins, most commonly Keratin 16 or Keratin 17, contributing to the assembly of a resilient intermediate filament network within the cytoplasm. This network supports epithelial integrity while enabling dynamic remodeling during processes such as tissue regeneration, inflammation, and cellular stress responses. Because of this biology, Keratin 6A antibody reagents are frequently used to evaluate epithelial activation rather than baseline differentiation status.
In normal tissues, Keratin 6A expression is typically restricted to specialized epithelial compartments, including basal layers of stratified squamous epithelia and regions undergoing active remodeling. In contrast, marked induction of cytokeratin 6A is a well-documented feature of pathological conditions characterized by hyperplasia, dysplasia, or aberrant differentiation. These include inflammatory skin disorders, epithelial injury responses, and a wide range of squamous cell carcinomas and other epithelial-derived malignancies.
Keratin 6A has particular diagnostic relevance in surgical pathology, where KRT6A antibody staining assists in distinguishing reactive or proliferative epithelial lesions from more quiescent tissue states. Its expression pattern complements other basal and stress-associated keratins, such as Keratin 5 and Keratin 14, providing additional resolution in epithelial tumor classification and margin assessment. Cytokeratin 6A antibody detection is therefore valuable for research focused on epithelial biology, cancer progression, wound healing, and stress-induced cytoskeletal remodeling.
1. Optimal dilution of the KRT6A/Keratin 6A antibody should be determined by the researcher.
2. This KRT6A/Keratin 6A antibody is recombinantly produced by expression in human HEK293 cells.
3. Manual Protocol: Freshly cut sections should be used (less than 10 days between cutting and staining). Heat-induced antigen retrieval for 5 minutes in an autoclave at 121oC in pH 7.8 Target Retrieval Solution buffer. Apply the antibody at a dilution of 1:150 at 37oC for 60 minutes. Visualization of bound antibody by the EnVision Kit (Dako, Agilent) according to the manufacturer's directions.
A recombinant fragment of human KRT6 (exact sequence is proprietary) was used as the immunogen for the KRT6A/Keratin 6A antibody.
KRT6A/Keratin 6A antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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