- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
KRT16 Antibody SPM264 / Cytokeratin 16 Monoclonal Antibody [clone SPM264] (V8928)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8928-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V8928-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V8928SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
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| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | SPM264 |
| Purity | Protein A/G affinity |
| UniProt | P08779 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE): 1-2ug/ml |
| Limitations | This KRT16 Antibody SPM264 / Cytokeratin 16 Monoclonal Antibody is available for research use only. |
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KRT16 Antibody SPM264 / Cytokeratin 16 Monoclonal Antibody recognizes keratin 16, a type I intermediate filament protein encoded by the KRT16 gene. Cytokeratin 16 contributes to the structural organization of stratified epithelial cells and is expressed in selected squamous epithelial compartments. Its distribution varies according to tissue specialization, differentiation state, and physiological stress. Unlike keratins associated with stable terminal differentiation, KRT16 frequently becomes elevated in epithelial cells undergoing activation or remodeling.
In stratified squamous epithelia, keratin expression patterns provide information about cellular identity and maturation. KRT16 commonly associates with type II keratins, particularly keratin 6, to form intermediate filament networks that support cytoskeletal organization. These networks contribute to epithelial resilience while accommodating changes in cell shape and tissue architecture. The expression of KRT16 can therefore reflect both structural requirements and alterations in epithelial differentiation.
Squamous epithelial tissues, including the oral cavity, tonsil, and upper aerodigestive tract, contain specialized cellular populations exposed to mechanical stress and environmental stimuli. Keratin expression differs among basal, suprabasal, and differentiated epithelial compartments. Immunohistochemical investigation of these patterns helps characterize epithelial organization and identify changes associated with inflammation, hyperplasia, or neoplastic transformation. KRT16 Antibody SPM264 is relevant to studies examining these tissue-specific expression patterns.
In tumor pathology, cytokeratin 16 has been investigated in squamous cell carcinomas and other epithelial malignancies. Altered keratin expression may accompany changes in cellular differentiation, proliferation, and invasive behavior. However, KRT16 is not a tumor-specific marker, and its expression may also increase in benign hyperproliferative or inflammatory conditions. Interpretation therefore requires consideration of tissue morphology and additional epithelial markers.
NSJ Bioreagents provides KRT16 Antibody SPM264 for immunohistochemical analysis of human formalin-fixed, paraffin-embedded tissues. The antibody recognizes a C-terminal region of keratin 16 and supports investigations of squamous epithelial differentiation, tissue organization, and pathological remodeling. The Cytokeratin 16 Monoclonal Antibody can be incorporated into research examining how intermediate filament expression changes across normal, reactive, and neoplastic epithelial populations.
Explore our Keratin 16 Antibody KRT16/2043R for additional research into KRT16 expression, epithelial differentiation, and keratinocyte responses to tissue injury and inflammation.
Optimal dilution of the KRT16 Antibody SPM264 / Cytokeratin 16 Monoclonal Antibody should be determined by the researcher.
A recombinant protein fragment from the C-terminal region was used as the immunogen for the KRT16 antibody.
Aliquot the KRT16 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Keratin 16 antibody, Cytokeratin 16 antibody, CK16 antibody, Keratin-16 antibody, Cytokeratin-16 antibody, K16 antibody
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