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- Tel: 858.663.9055
- Email: info@nsjbio.com
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
Titration of the KRAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 146-174 from the human protein was used as the immunogen for this KRAS antibody.
Aliquot the KRAS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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