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Home >> Antibodies >> KEAP1 Antibody

KEAP1 Antibody (R32225)

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  Catalog No Formulation Size Price (USD)  
Image R32225 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) HeLa, 2) MCF7 and 3) SW620 lysate wtih KEAP1 antibody. Expected/observed molecular weight ~70 kDa.
Western blot testing of human 1) HeLa, 2) MCF7 and 3) SW620 lysate wtih KEAP1 antibody. Expected/observed molecular weight ~70 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt Q14145
Applications Western blot : 0.1-0.5ug/ml
Limitations This KEAP1 antibody is available for research use only.
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Description

KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 is a protein that in humans is encoded by the KEAP1 gene. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. In the presence of the electrophilic agent diethylmalate, Nrf2 activity is released from Keap1 and Nrf2 translocate to the nucleus. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

Application Notes

Optimal dilution of the KEAP1 antibody should be determined by the researcher.

Immunogen

Amino acids 25-205 of human KEAP1 were used as the immunogen for the KEAP1 antibody.

Storage

After reconstitution, the KEAP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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