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Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. [UniProt]
Optimal dilution of the KATNA1 antibody should be determined by the researcher.
A synthetic peptide derived from human Katanin p60 ATPase containing subunit A1 was used as the immunogen for the KATNA1 antibody.
Store the KATNA1 antibody at -20oC.
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