- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
KAT5 Antibody / Tip60 / 60 kDa Tat-interactive protein (RQ7084)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7084 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q92993 |
| Applications | Western Blot : 0.5-1ug/ml Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This KAT5 antibody is available for research use only. |
|
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KAT5 Antibody targets lysine acetyltransferase 5, a nuclear histone acetyltransferase commonly known as Tip60 and encoded by the KAT5 gene. Tip60 is a member of the MYST family of histone acetyltransferases and functions as a central regulator of chromatin structure, transcriptional regulation, and DNA damage response pathways. Through its enzymatic activity and participation in multiprotein complexes, KAT5 plays a critical role in maintaining genomic stability and coordinating nuclear signaling events in response to cellular stress.
Functionally, Tip60 catalyzes the acetylation of histone substrates, including histone H4 and histone H2A variants, leading to increased chromatin accessibility and facilitation of transcriptional activation. In addition to histones, KAT5 acetylates a range of non-histone proteins involved in DNA repair, cell cycle control, and apoptosis regulation. These acetylation events influence protein stability, protein-protein interactions, and signaling outcomes, positioning Tip60 as an integrative regulator of transcriptional and stress response networks. A KAT5 Antibody supports studies focused on epigenetic regulation, histone acetylation dynamics, and nuclear signaling mechanisms across diverse biological contexts.
KAT5 is predominantly localized to the nucleus, consistent with its role in chromatin-associated processes. Within the nucleus, Tip60 functions as part of large multiprotein assemblies that link histone acetylation with ATP-dependent chromatin remodeling, transcription factor recruitment, and DNA repair machinery. Subcellular distribution and activity of KAT5 can vary depending on cell type, developmental stage, and cellular stress conditions, reflecting dynamic regulation of its interaction partners and enzymatic function. These features highlight Tip60 as a responsive chromatin regulator rather than a static epigenetic modifier.
At the molecular level, KAT5 contains a conserved MYST acetyltransferase domain that mediates catalytic activity, along with additional regions that facilitate protein-protein interactions within chromatin-modifying complexes. Structural features of Tip60 enable coordinated regulation of acetylation events and integration with broader chromatin remodeling processes. Post-translational modifications of KAT5 itself, as well as regulated complex assembly, further fine-tune its activity and functional specificity in different cellular contexts.
From a disease relevance perspective, altered Tip60 expression or activity has been investigated in cancer, neurodegenerative disorders, and other conditions associated with genomic instability and dysregulated transcription. KAT5 has been implicated in tumor suppressor pathways through its involvement in DNA damage signaling, apoptosis regulation, and maintenance of chromatin integrity. Disruption of Tip60-mediated acetylation can affect cellular responses to genotoxic stress and influence cell fate decisions, underscoring the importance of KAT5 in preserving nuclear homeostasis. KAT5 Antibody reagents support research applications examining epigenetic control mechanisms, chromatin remodeling pathways, and DNA damage response signaling, with NSJ Bioreagents providing antibodies intended for research use.
Optimal dilution of the KAT5 antibody should be determined by the researcher.
Recombinant human protein (amino acids M1-E56) was used as the immunogen for the KAT5 antibody.
After reconstitution, the KAT5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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