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Home >> Antibodies >> Kappa Light Chain Antibody

Kappa Light Chain Antibody [clone KLC709] (V2150CF488)

  Catalog No Formulation Size Price (USD)  
Image V2150CF488-100T 500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 Tests 519
Microvalidated
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using anti-Kappa light chain antibody (clone KLC709). These results demonstrate the foremost specificity of the KLC709 mAb.
Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
Availability 1-3 business days
Species Reactivity Human
Format CF488 Conjugate
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name KLC709
Purity Protein G affinity chromatography
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Kappa Light Chain antibody is available for research use only.
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Description

This antibody is specific to the kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general, the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Application Notes

Optimal dilution of the Kappa Light Chain antibody should be determined by the researcher.

Immunogen

Recombinant human Kappa light chain was used as the immunogen for this Kappa light chain antibody.

Storage

Store the Kappa Light Chain antibody at 2-8oC, protected from light.

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