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- Tel: 858.663.9055
- Email: info@nsjbio.com
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The ITGA4 gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [RefSeq]
Optimal dilution of the ITGA4 antibody should be determined by the researcher.
A synthetic peptide specific to human Integrin alpha 4 / ITGA4 was used as the immunogen for the ITGA4 antibody.
Store the ITGA4 antibody at -20oC.
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